Coach Wooden’s Pyramid of Success Essay Example

Coach Wooden’s Pyramid of Success Essay Irma Sanchez Period 3 11/14/12 Pgs: 159 Coach Wooden’s Pyramid of Success By: John Wooden John Wooden was an amazing coach during his time, he won many championships and he is a big reason why UCLA was as successful as they were. Coach Wooden, in this reading, teaches me and many others who read how you can’t just wish for success, being successful is something you have to work at every day. Also, not only working everyday like getting more practice and more repetition, that is not what Coach Wooden is trying to teach here he teaches that being successful comes from inside. He explains how in order to be successful you have to have traits like loyalty, self control, confidence, cooperation, and of course skill. Reading about Coach Wooden’s Pyramid of Success is really something I agree with 100%, I am not sure if it is because I am also an athlete so I am able to relate to his motivation and his way of words. I mainly agree, because he is right about all that he says everything he mentions in the pyramid are all things you not only need to be a successful athlete, but to be a successful person which is why I agree with what Coach Wooden has to say so much, because anyone can read this book and learn from it not just athletes. I personally completely enjoyed this book, because I am an athlete and as a softball player I know my strengths just as well as I know my weaknesses. We will write a custom essay sample on Coach Wooden’s Pyramid of Success specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Coach Wooden’s Pyramid of Success specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Coach Wooden’s Pyramid of Success specifically for you FOR ONLY $16.38 $13.9/page Hire Writer I know I have trouble with being sure of myself and being confident in what I can do on the field. Although, I am a player that wants to be successful more than anything else in the world I am willing to go through anything and everything you can think of if it will make me a better athlete. When I read Coach Wooden’s book I realized you need poise and confidence in order to reach all the success you want and that really changed me, because I have that motivation and that drive to be successful in every way that I can. Also, poise and confidence weren’t just on the pyramid of success they were at the very top on the second row on this pyramid, so that just goes to show that confidence and poise are two things I really should work on as a person and as an athlete if I want to reach all the potential I know I can. Since I am motivated to be the best I can be, since I have that competitive fire to have all the potential in the world I read this book and I am motivated to get better in every trait he has in that Pyramid of Success, because I know the history he has left behind he is nothing but full of absolute success. I want to reach all the success he had while he was coaching so I will listen to his words with complete respect, and I will trust everything in his stories because I personally know I want to be successful. I really do believe that anyone can connect to this book, I connected to this book because I am a motivated athlete thriving to be better each and every day, but if you are simply motivated to be the best you can be you will become more successful after this book, you don’t only have to be an athlete. You can learn a lot of good traits to have from this book to make you a better person.

Fraternities and Sororities and Fraternity Essay Essay Example

Fraternities and Sororities and Fraternity Essay Essay Example Fraternities and Sororities and Fraternity Essay Essay Fraternities and Sororities and Fraternity Essay Essay When we hear the word â€Å"frat† it comes to our head that it’s a group of people that making something in possible and bad influence for the pupils like us. All the things around that may destruct our surveies. And we are all familiar to this because it is widely known for different name of groups of people who are organized it. And we are besides cognizant to the consequence of it due to the intelligence about what happened to the member of this group that is being abused. And some are died because they can non last to what they are making. And this is normally happen in different schools that have a large population of pupil merely like universities. Because the frat members can non easy notice if they were involve. due to many pupils in that topographic point. Not merely like in the school which has fewer Numberss of pupils is really noticeable when there is a fraternity. The word fraternity came from the Latin word â€Å"frater† which means â€Å"brotherâ €  otherwise is a brotherhood. though the term sometimes connotes a distinguishable or formal organisation and a secret society. A fraternity is a male-only association with members who are linked by common involvements of some signifier or another. . : Peoples who wish to fall in typically take part in activities which take topographic point over the class of a hebdomad at the start of a semester. Since most colleges with a fraternity system have multiple fraternities. these events normally take topographic point during the same hebdomad at all fraternities. leting people to research all their options. This period is known as â€Å"rush week† . After first-come-first-serve hebdomad. current members of the fraternity decide which members should be voted in. Traditionally. new pledges participate in an induction ceremonial which has historically been accompanied by hazing challenges. Due to concerns about the hazards of hazing challenges which involve unsafe activities and imbibing. many colleges have explicitly banned hazing in the involvement of pupil safety. Some colleges have besides cracked down on fraternity parties in response to ailments from other pupils and the environing community. Membership in a fraternity can confabulate many advantages. It is non uncommon for fraternities to keep living quarters and private nines which are merely unfastened to their members. Particular scholarships may be available. and fraternity rank can be used for networking which will be valuable subsequently in life. Many people besides enjoy the brotherhood which comes with fraternity rank. From Internet ( researches ) The old apprehension was that it was typical for a fraternity to be all-men group while sorority was all-women group. However. there is such thing as a sister sorority or a brother fraternity. While in theory they are separate organisations. but in pattern they are one. They believe in the same rules. They pattern the same tradition and they have the same mission. vision and methods of work. As such. there is a good ground to unite the fraternity and sorority to unite the organisations. However. long clip ago. there were already fraternities who accepted female members who were extremely qualified to the criterions of the fraternity. This happened in I?AE at Central Mindanao University. Musuan Bukidon. Philippines in 1966. This resulted to a mixed-sex organisation. Then in the ulterior old ages. there were unifying of the brother-sister organisations. But in some instances. the sorority is absorbed by the fraternity instead than merged. therefore retaining the name of the latter. The re are patterns in the fraternity/sororities that merely the members are privileged of take parting and/or basking them. These patterns are traditions that the organisations are keeping which are by and large symbolic in nature but are closely guarded with exclusivity. In add-on to the naming of brod or sis. there are the watchwords. vocals. special/exclusive handshakings. tattoos. slogan. usage of badge or pin. frat spine. or even a frat whistling. colourss. flag. flowers. or seal. It has a slogan to show the ideals of the fraternity or sorority. They are really important to the organisation. They remind them of their pledge of commitment to the brethren. Some Greek-letter organisations have acquired juridical personality to conform to local legal law. This had widened the positions of the organisations to prosecute and/or participate in some public enterprises necessitating licenses and/or licences. For illustration. Sigma Alpha Epsilon Fraternity â€Å"Philippines† is registered with the Securities and Exchange Commission under Registration No. CN200429554. In a simple linguistic communication one joins a fraternity/sorority because he/she believes it is good for him/her. and he/she likes to be one of its members. Virtually. common sense will state us that we would merely voluntarily fall in an organisation if it is good to us. And if we do non like the members of that organisation we would non besides voluntarily fall in. more so if new entrants would endure in the procedure of fall ining like induction and hazing. The North-American Inter fraternity Council ( NAIFC ) as posted in the cyberspace suggested to see some of the ways Greek life can positively act upon your college calling and the remainder of your life. The first manner is to be successful in life which means desiring to make good academically. to graduate on clip and happen a good occupation. and to hold wise mans and friends to assist me develop as a pupil and as a individual. This is possible because fraternities/sororities stress academic excellence and many alumnas members can assist occupation arrangement. The 2nd manner where your life can be influenced positively harmonizing to NAIFC is to be a better individual. This means desiring to be a leader. to work efficaciously and to face inappropriate behaviour. to larn to interact socially. and to be a responsible individual among other things. The 3rd manner is to organize womb-to-tomb friendly relationship. This means desiring to happen a close-knit of friends assisting one another with common values and involvement. When I started college in 1962 I was a lone wolf. even introvert. and had neer been involved in extra-curricular activities. Then I joined a fraternity in 1966. and I became a campus figure. The 4th manner where your life can be influenced positively harmonizing to NAIFC is to hold fun in college. This means desiring to take part in campus events. to hold emphasis alleviating activities. and run into new people making new things. Before I joined a fraternity. pupil life was truly deadening. All surveies without drama. I was good in faculty members but really hapless in political relations. I was really hapless in leading and human dealingss. After I joined a fraternity I became the president of two major campus organisations. the News Editor of the school organ. the Editor-in-Chief of the Annual Yearbook. and was appointed as the Secretary of the Department of Internal and External Information of the Executive Branch of the Student Body Organization. In add-on to the predating study of NAIFC. Cesar Gonzales. a Daily Titan Staff Writer in his article posted at the Internet on December 11. 2009 corroborated the same by stating that. Being in a fraternity builds friendly relationship and character. Rightly said ; in fact this is a familiar statement one will hear when person is asked why he/she joined a fraternity or sorority. But his thought that one joined a fraternity to acquire the full college experience and to hold merriment and run into new people to be able to populate the college life needs farther account. I rather agree with the thought but I have some reserves. In fact the members that I met for the first clip became my brothers and sisters ; non merely friends. But fraternity work is non all for merriment. It is possible that Greek-letter organisations vary in aims. mission. vision. and methods of work. But I’m certain that many fraternities/sororities consider rank a lifetime committedness of constructing a wholesome household characterized by love and integrity. Loving is non ever for merriment. Most frequently than non. it is denying oneself in order to execute service. Loving person is accepting a duty. Anyway. one time you’re a member of a fraternity/sorority. you are expected to take part in many events like meetings. conferences. seminars and other clip devouring committednesss. And there are of these organisations that conduct group surveies and reappraisal for term scrutiny. Of class there are fun-related activities like parties. field daies. jaunts or athleticss. But ever the intent is acquiring to cognize you. In some ways. being a fraternity or sorority member is more like of taking a lifestyle than merely for leisure. To be a good member one has to be willing and available for these events. But many people have the incorrect impression that fraternity or sorority life is all about partying. So unluckily. negative stereotypes about fraternity/sorority life are abundant and fellow pupils. even friends will judge you cruelly because of your rank. This is hence a existent challenge to Greek-letter organisations to turn out otherwise. There are fraternities/sororities that academic accomplishment among other things is a serious concern. Their attitudes towards analyzing and run intoing high pedant records are really positive. So. when you have this sort of fraternity/sorority. the feeling that fall ining these organisations would eat up your clip and consequence to the disregard of your surveies is non at all a sweeping statement. In fact most fraternities/sororities I knew require that those who would come in plighting must hold no neglecting classs. The advantages of fall ining a fraternity or sorority was besides emphasized by Harlan Cohen in his article Greek Life posted on September 24. 2007 that there are chances for leading one time you join this sort of organisation. He said that so much of Grecian life is about accomplishment and leading and the pupils who make up the largest per centum of leaders on campuses are Greeks. I agree with all of these. I will unwrap latter that all of the establishing members of my fraternity occupied top ranking elected and appointed places in the pupil organic structure organisation and were leaders in civic and societal organisations in the campus. But Cohen on the other manus besides enumerated the disadvantages in fall ining a fraternity/sorority. One is clip committedness that competes with survey clip that the student’s classs may endure. This contradicts to the aim of academic excellence of a fraternity/sorority. Cohen farther said that another disadvantage of fall ining a fraternity/sorority is money. indicating out that there can be an atrocious batch of incidental disbursals. Actually. this is non true to all fraternities. In my fraternity and sister sorority. our fiscal duty was merely one peso per hebdomad. Then. Cohen besides said that there is besides that danger of exposing oneself to enticements of sex and intoxicant. This is possible. but the truth is deficiency of morality and indulging to frailties can go on to anybody ; member or non member to these organisations. It depends on the individual. Possibly bad company. or hapless household upbringing. or deficiency of supplications can be one of the causes. But it is non by and large correct to impute the bad luck to the fraternity or sorority. Coming to college is one of the major life alterations that your boy or girl will travel through. Joining a fraternity or sorority chapter will assist do the passage easier. Developing womb-to-tomb friendly relationships with the members in their chapter helps do the campus seem smaller. For many members. these chapters become a place off from place. In add-on to the brotherhood/sisterhood. every chapter is dedicated to heightening leading. scholarship. and philanthropy/community service. These ideals form the foundation of the fraternity and sorority experience. and are upheld within a civilization of support and growing through academic support plans. leading preparation and hands-on experience. educational workshops. societal events and undertakings for community service and philanthropic gift. In my instance I co-founded Sigma Alpha Epsilon Fraternity-Philippines to set up support system among technology pupils in order to complete the class on clip and base on balls successfully the Board Examination. In add-on to our concern for high academic public presentation. we besides wanted to larn leading in campus organisations and other extra-curricular activities. And since I didn’t like the patterns of the bing fraternity in the campus. we decided to organize a new fraternity that will transport out our beliefs. inspirations and ideals. So the issue of disbursals. clip for analyzing. alcohol addiction. or even acquiring involve with the opposite sex were neer a concern in the organisation. It was earlier mentioned that rank to these organisations is lifetime. Hence. after graduation the alumnas members carry with them the rights and benefits of rank. That’s why in her article posted in the website October 16. 2006 entitled Grecian Life: Advantages. Naomi Rockler Gladen said that â€Å"When you’re looking for a occupation a few old ages from now. your accomplishment set frequently is non every bit of import as your connexions. This is unfortunate. but it’s a world. Grecian rank is a great manner to link with people. both in your pledge category and through members who have graduated and joined the on the job universe. I know of a esteemed private corporation in Manila. Philippines that is owned by a member of Sigma Alpha Epsilon where all the employees ; supervisors and rank-and-files belong to the same fraternity.

Police Brutality Research Paper Example | Topics and Well Written Essays - 1000 words

Police Brutality - Research Paper Example Roberts (2011) pointed that in youtube alone, an e-site containing video records, produced about 497,000 results when "police brutality" is subjected to the search engine. Roberts (2011) described that these videos either depict beaten women, kids and the aged or violent and bloody exaction of testimonies from unwilling suspects. Some testimonies of victims who were able to undergo sad ordeal revealed electrocution; suffocation, psychological torment or threat; emotional shocks; direct physical assault, and the like done by police with psychopathic and sociopath tendencies. Skolnick and Fyfe (1993) explicated that police brutality brought along with it such dehumanizing intent by treating the target with such concealed venality and such degrading impact of violent torture. Roberts (2011) attributed this inhuman way of managing suspects, civilians and victims to militarist treatment as abuse of power. Those who are involved in police brutality tactics are characterized with such nastiness as they were trained to view the public, the people whom they ought to secure, as their enemy. To some extent, some police officers have made policing activity leveled beyond preservation of order into cyclical patterns of injustice as commission of human rights. Often logged without witnesses to corroborate the conduct of brutalities, Bandes (1999) noted that authorities would just label this as an incident which is either isolated, systemic, or part of a larger pattern to suppress a movement. Bandes (1999) explicated that police brutality are often portrayed by court as something anecdotal, fragmented and isolated from institutional pattern (p. 1275) reinforced by causes that could be political, social, psychological and cultural (Bandes, 1999, p. 2). Experts opined that victims of police brutality would have difficulty expressing such unfair victimization because complaints about it are discouraged due to a dearth of evidence, lack of corroborative testimonies, records are expunged, and police records are purposively made inaccessible.

Principles of Finance Essay Example | Topics and Well Written Essays - 2000 words

Principles of Finance - Essay Example The composition and determination of the perfect capital structure has been an integral subject of research in corporate finance. The Nobel Prize winner theorem presented by Modigliani and Miller is the cornerstone of capital structure in today’s world. The crux of the theory is that under an effective market where there are no taxes, insolvency costs, agency costs, and asymmetric information, the value of a business is not established by sources of finance (Modigliani and Miller). They advocated that under perfect market condition, without any friction, the capital structure of the company does not influence its market value. Therefore, it is irrelevant whether an entity finances its capital by issuing shares or raising debt and the like ways. Similarly, an entity’s dividend policy is immaterial. Owing to these factors, this thermo is also termed as capital structure irrelevance principle. For instance, suppose there are two firms which are similar in every way except for their capital structures. One firm is financed merely through equity and the financial structure of the other one comprises of both, equity and debt (Miller). According to the ‘capital structure irrelevance principal’, both companies will carry the same worth. ... He went on to elaborate, â€Å"The Modigliani—Miller proposition says that if there were no costs of separation (and, of course, no government dairy support program), the cream plus the skim milk would bring the same price as the whole milk†. The heart of this analogy was that expanding debt (cream) diminishes the worth of existent equity (skimmed milk). If secure cash flows are sold to debt holders, the firm will possess lesser worth equity; hence, the aggregate worth of the firm will remain unaltered. In other words, the gain from what appears cheaper debt is set off against the riskier and more expensive equity. Thus, the constitution of capital from debt and equity would be futile, given a certain quantity of aggregate capital. This is because the weighted average for any possible compositions of the two finance alternatives to the firm will remain unaffected. However, the condition of perfect condition is restricted to theorems so businesses in the real world are n ot subject to this environment. In addition, it is extremely rare for the capital structure of a company to be completely based on debt. Myriad arguments have emerged in opposition to Modigliani—Miller theorem; these accentuate taxation, agency costs, insolvency, equity dilution, credit rationing, conflicting interest of management etc. Modigliani and Miller recommended for firms to have a certain borrowing ability in case of an economic upheaval. Taxes The most evident drawback of the Modigliani—Miller theorem is the supposition the subtraction of interest and corporate taxation. Under most financial frameworks, tax cannot be computed until the deduction of interest owed to debt holders from the corporate profits. Therefore, the amount of corporate tax not charged serves as a subsidy based on

Term paper Example | Topics and Well Written Essays - 1250 words

Term Paper Example During the nation’s early years, this electoral process was effective under a Federalist government, however the need to revise the electoral process with regards to the instatement of the members of the Senate was borne out of the need to further expand democracy, eliminate corruption tied to the election of Senators, and to remove external control over the creation of state legislatures (Neale 3). Also, relying mostly on the votes of the state legislatures caused election deadlocks which prevented the appointment of Senators and subsequently, unfilled senate vacancies for considerable periods at a time (4). This created additional problems with regards to the creation of new laws since the Senate members have longer terms of service than the members of the House of Representatives. Thus, after 124 years of relying on state legislatives on electing Senate members or waiting for the governors to appointment a replacement should a senator leave office, the Seventeenth Amendment was finally ratified on April 8, 1913 which allowed the election of Senators through popular voting (6). ... James Madison is one of the strong proponents on the upkeep of the constitution as well as in preventing most of its amendments, especially since he believes that there is great difficulty in the process of men governing over other men (70). There must be an overall control to all members of the government in order to prevent the human inclination of following actions or decisions that came about due to vested interests, as well as to prevent the over-reliance on religion and virtue which are both subjective in nature. Also, Madison believes that a continuous process of amending the constitution would not only create problems such as the inability of most people to follow laws and regulations properly due to the inaccuracies that can be encountered after several changes were made in the original laws, thus rendering the laws much more ineffective (71). In addition, it is expected that the constitution was already a functional one since it was created by a wide variety of people, in s uch a way that there is a less probability that a majority of the people would be making motives that undermine the rights of the common people (73). Thus, if the constitution was made out of the various ideas and input by different individuals, it essentially governs all members of the nation, using the principles of justice and of the common good as applicable to all walks of life. In addition to the need to retain the constitution as close to the original as possible, the Founding Fathers aimed to prevent the rise of aristocracy through the ruling of only a few people and the establishment of true democracy by allowing more people to participate in the process of governance. This may

Drug Discovery Process Of The Bio Pharmaceutical Industry Biology Essay

Drug Discovery Process Of The Bio Pharmaceutical Industry Biology Essay The development of new pharmaceutical products is a long, expensive and uncertain process. It takes an average of 10 to 15 years for a new drug to move from the discovery phase into the marketplace, and the average cost for the development of a new drug is approximately $800 million. Out of 6000 compounds initially screened, only 6 are selected to move onto clinical trials, and out of those 6, only 1 compound is approved by the Food and Drug Administration (FDA) and the product is introduced into the market. The low success rates associated with new drug development is what makes the demand for resources at different stages of the development pipeline highly variable and very difficult to predict. Even after a drug is launched into the market, success is not guaranteed as toxic side effects may erupt when the drug is introduced to a larger sample of diverse population. This unpredictable process together with the companys annual fixed cost of Research and Development creates a major financial risk. Nevertheless, pharmaceutical firms decide to undertake this risky process because of the opportunity to develop a blockbuster drug, a drug that generates $1 billion or more each year in sales revenue for the company, and has the capacity to meet unmet medical needs of the population. Pre-Discovery To Understand the Disease Before any potential new medicine can be discovered, scientists work to understand the causes as well as other underlying factors in relation to the disease to be treated as well as possible. Target Identification (Choose a molecule to target with a drug) Once they have enough understanding of the underlying cause of a disease, pharmaceutical researchers select a target for a potential new medicine. A target is generally a single molecule, such as a gene or protein, which is involved in a particular disease. Even at this early stage in drug discovery it is critical that researchers pick a target that is drugable, i.e., one that can potentially interact with and be affected by a drug molecule. Target Validation (Test the target and confirm its role in the disease) After choosing a potential target, scientists must show that it actually is involved in the disease and can be acted upon by a drug. Target validation is crucial to help scientists avoid research paths that look promising, but ultimately lead to dead ends. Researchers demonstrate that a particular target is relevant to the disease being studied through complicated experiments in both living cells and in animal models of disease. Various stages in Drug Development Process The drug development process is highly regulated and follows a number of well-defined steps and milestones. Discovery and screening stage Emerging tools in molecular biology, cell biology and combinatorial chemistry help researchers understand diseases and identify specific targets for new drugs. Once a specific target is identified, drug development starts with the screening of a large number of compounds to find the non-toxic compounds with the desired biological effects. Typically, thousands of chemical compounds are tested in test tubes or individual cells (tissue cultures). Drug companies maintain large libraries of newly synthesized or isolated compounds. Compound from these libraries are tested for biological activity. Preclinical testing Preclinical testing involves a series of short term and long term animal and laboratory tests to generate data on if a compound is safe and worthwhile to test on people. The aim of preclinical testing is to understand what happens when the drug is metabolized, as well as to generate information about the optimal dose for the clinical trials. Animal studies provide data on the absorption, distribution and excretion of the compound. The chemical properties of the discovered compounds are studied in significant detail at this step. Steps for synthesis and purification are developed at this time. These help identify any acute toxicity issues that may arise. It usually takes 3-4 years to gather data in support of Investigational New Drug Application (IND). This application notifies the Food and Drug Authority (FDA) of the drug sponsors intent to conduct clinical research on human. In parallel with the animal studies, the company has to conduct studies to determine how to manufacture repro ducible batches over time. Clinical trials The ultimate goal of clinical trials is to determine whether the drug works well enough in patients. The trials should address: whether the risk of toxic side effects outweighs the therapeutic benefit; which dose regimen provides the best response and the least number of side effects; if the drug is better than existing treatments or not. Clinical trials are divided in three phases Phase I (PI): In Phase I trials, the candidate drug is tested in people for the first time. These studies are usually conducted with about 20 to 100 healthy volunteers. The main goal of a Phase I trial is to discover if the drug is safe for humans. Researchers look at the pharmacokinetics of a drug: How is it absorbed? How is it metabolized and excreted from the body? They also study the pharmacologics of a drug: effects of the drug on the functioning of the human body. These closely monitored trials are designed to help researchers determine what the safe dosage range is and if it should move on to further development. Phase II (PII): The goal of this phase is to evaluate the effectiveness of the drug for a particular indication and how the drug behaves in people. These studies typically include 100-500 patients with a target disease or indication, divided into several subgroups. The subgroups are administered the drug in different dosages, by different routes, and on different schedules. Efforts are made to determine the common short term side effects and other risks associated with the drug when used on human beings. Phase III (PIII): The studies in this phase are conducted over a long term and on a large sample of 1000-1500 patient volunteers. The basic aim of this phase is to generate statistically significant data, about to evaluate the risks and benefits associated with the drug. The effectiveness and safety of the drug is carefully examined and dosing regiments duly noted which will lead to the FDA and the international regulatory agencies to approve the new drug. The results from these studies are used to develop the DRUG LABEL. The Drug Discovery process has many issues like Long Lead Times and Uncertainty that are plaguing the whole process and causing disturbances/tremors along the lines of New Product Development. Literature review A stochastic programming approach for clinical trial planning in new drug development Matthew Colvin, Christos T. Maravelias Due to changing circumstances in the managed-health-care environment, the profit margins of pharmaceutical companies and the productivity of their Research and Development (RD) pipelines have started to decline; effective patent lives have been shortened, and patents provide lower barriers to entry even while active. Therefore, it is imperative for pharmaceutical companies to manage their RD pipelines more effectively to reduce the cost of developing new drugs. This is a challenging task due to the highly stochastic nature of the RD process: if a drug fails a clinical trial, its development stops and all prior investment is lost; if it passes all trials, it enters the marketplace and profits are typically significantly larger than development costs. To effectively plan the clinical trials in the pharmaceutical RD pipeline, therefore, new systematic stochastic optimization methods are necessary.The paper presents a multi-stage stochastic programming formulation for the scheduling of c linical trials in the pharmaceutical research and development (RD) pipeline. The stages correspond to time periods, i.e. the planning horizon is divided into multiple periods. Scenarios are used to account for the endogenous uncertainty (a drug either passes or fails a clinical trial) in clinical trial outcomes. Given a portfolio of potential drugs and limited resources, the model determines which clinical trials (PI, PII, PIII) to be performed in each planning period and scenario in order to maximize the expected net present value of the RD pipeline. The proposed formulation can be used to address problems of medium size and serves as a basis for the development of advanced models for the management of the pharmaceutical RD pipeline. Knowledge networking to support medical new product development Kannan Mohan, Radhika Jain, Balasubramaniam Ramesh Pharmaceutical firms depend heavily upon their ability to rapidly develop and introduce new products into the market. Product development speed directly impacts their financial bottom-line as well as their ability to satisfy unmet medical needs of patients. However, development of new medical products is complex and time-consuming. It takes anywhere between 7 and 17 years and several millions to billions of dollars to launch new medical products. Some of the factors contributing to the length, cost, and uncertainty of this process are the stringent regulatory requirements of governmental entities like the FDA requiring the maintenance of design history for every medical product to show that the products were developed as per the approved plan and with extensive clinical trials, medical products are used to treat human beings whose well-being and safety are of utmost importance. Thus, failure of the product can have serious consequences, increasing possibilities for therapeutic interv ention brought about by newer technologies and enormous investments required in research and development, and testing. This paper addresses the issue of developing an approach to seamlessly integrate fragmented knowledge using knowledge networks. Semantic knowledge networks provide the ability to describe and follow the life of a physical or conceptual artefact. These have been used as effective solutions to support knowledge integration in knowledge intensive processes in multiple domains. Motivated by their effectiveness in supporting knowledge intensive processes, the paper proposes the creation and use of knowledge networks to facilitate integration of knowledge fragments that are generated and used in medical NPD. The development of a knowledge network should be guided by the unique characteristics of the medical NPD domain. The paper also provides the background on the process of medical NPD, along with unique issues in this area. New product development process and time-to-market in the generic pharmaceutical industry Janez Prasnikar, Tina Skerlj This article presents some important factors impacting on the lead-time of new products. In particular, we find a negative relationship between the incorporation of organizational tools and techniques, such as concurrent activity management and time-to-market. Further, there is an appropriate negative relationship between the integration of new product development departments in particular phases of the new product development process and the cycle-time of those phases. Appropriate capacity management and project management also contribute to a shorter lead-time of a new product. However, there are also some particularities of generic pharmaceutical companies. The retargeted products (where an existing product is launched in a new market) have longer time-to-market than completely new products. The generic pharmaceutical industry depends very much on local market conditions and it is often easier to launch new products in already existing markets than to launch existing products in n ew markets. Further, if the active pharmaceutical ingredient is sourced externally the time-to-market is shorter. The same is true of the external sourcing of the pharmaceutical formulation. Since generic companies often build their competencies in the market rather than on the technology used, strategic alliances and early supplier involvement in the new product development are important factors of their market success. Research objectives The Biopharmaceutical industry has many a process to be deeply understood and uniquely mapped, however, I would be looking at the following for the purpose of my project To understand the Drug Discovery Process and map it with New Product Development Understand how a pharmaceutical product is produced; identify all the stages from the Pre discovery phase to the Discovery phase and from the Pre clinical phase to the Clinical Phase and map it with New Product Development Identify the sources for reducing Uncertainty in the Drug Discovery Process One of the features that restrict the smooth functioning of the Drug Discovery process is uncertainty about the drug in trail. If the drug that is being tested fails the clinical trials phase, all the investment and effort towards drug development is lost, but if it passes all the trials, it enters the marketplace and benefits the company by providing profits that are typically significantly larger than the development costs. Identify the sources for reducing Lead Time in the Drug Discovery Process Drug development in the pharmaceutical sector is a lengthy process ranging anywhere from 7 to 17 years and costs the companies billions of dollars. Thus identification of sources for reduction in lead time and appropriate application of those steps would directly influence the costs and help in launching the product quicker than usual into the market. Research methodology Interaction with Biopharmaceutical Teams working on the Drug Discovery Process at the Biological Sciences and Biological Engineers (B.S.B.E) department at Indian Institute of Technology, Kanpur Secondary Research from Scientific Journals Case study approach in Business Press and Scientific Journals Chapters Introduction to the Drug Discovery Process Detailed explanation of the Drug Discovery Process Convergence with the New Product Development Literature Review Analysis of the related topic as described in Business Press and other Scientific journals. Research Objectives Research Methodology: An outline of the different approaches available for research Explanation of the different approaches and their outcomes with respect to the project Results and Discussions of the case Management Insights Relation of the Drug Discovery Process with Management concepts Conclusions and Future Research

Eve’s Ribcage :: Essays Papers

Eve’s Ribcage Eve’s bedroom was the only place in the world that Josh felt comfortable. The bare and slightly yellowed walls held a certain mysterious wonder for him. The key to the room’s beauty lay in its bareness and simplicity, like old Mexican monasteries with terra cotta tiling on the roof. Josh preferred to keep the lights off and the blinds cracked so that the afternoon filtered in through the window, making thin picturesque rays of light. They painted Eve’s body in long soft strips of sun. When she reclined on her side in the way that she did it reminded him of those nature documentaries that film a lioness lying around in tall grass all day, waiting for dumb animals with long legs to run by and get killed. She was all taut muscle under brown skin accented with bold shadows, a delicate but solid frame slowly rising and falling with each breath. Eve’s feral qualities manifested themselves in her face especially. That strange expression she had: a mixture of pain and pride, boredom and beauty. Her face was always beautiful, no matter what expression she chose to wear. Her sad almond eyes would stare through Josh and beyond into deeper things. This made him want to ask her what she was thinking about, but he rarely ever did. April’s answers never shed light on the mystery of her melancholy and oftentimes they seemed to push him further away. Now she lies with her back facing him, the contour of her naked body a soft watercolor landscape of hills and valleys. He feels like a tourist lying beside her for the last hour or so; absorbing her, analyzing her, thinking about her. She gazes into heaven and talks to the angels while he lies beside her and marvels like a man who has at last reached the end of a long holy pilgrimage. Share my world Don’t you leave Promise I’ll be here Whenever you need me near†¦ Mary J. Blige croaks out her sultry ballad softly in the background. â€Å"Eve†¦Ã¢â‚¬  Her name echoes and makes him feel he as a separate entity all the more acutely. â€Å"You okay?

Recruitment Strategies

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REFERENCES 558 INDEX 0-C checklist 68–72 360-degree assessments 424 absence management 166–8 achievers 414–15 acquisitions 301–3 action learning 293–5, 476 active labour market programmes 119–20 Advisory, Conciliation, and Arbitration Service (ACAS) 530–1 affective identification 243 age discrimination 506 aircraft industry 97 alienation 7 ALMPs (active labour market programmes) 119–20 analyser organizations 320 anger 306–7 anti-discrimination legislation 142 applications for employment 361–5 appraisal-related pay 443 appraisals 419–22 apprenticeships 147, 148 arbitration 529–31 Ark Nurseries 259 Asia, war for tale nt 85–6 assessment centres 393–5 astronauts 355 attitudes 133–4 Australia commitment 245 employee education 146 employee perceptions 238 employee relations 520–2 flexible working 326 human resource information systems 62 nurses 175–6 work experience 146 Australian Institute of Industrial Psychology 8 authoritarianism 5 balanced scorecards 53 bargaining 532–3 BARS (behaviourally anchored scales) 428 behavioural compliance 243 behavioural consistency 39 behavioural interviews 388 behavioural observation scales 428 behavioural transformation 308–10 behaviourally anchored scales 428 benchmarking 65 benefits 439–42 best practice model 32 biodata 365–8 blended learning 477–8 bonuses 444 boomerang kids 105 BOS (behavioural observation scales) 428 BPR (business process re-engineering) 226, 295–300 BR (British Rail) 379 bribery 133 Britain see United Kingdom British Rail 379 broadbanding 437 burnout 172 business eff ectiveness 57–60 business environment 77 business goals 182–3, 275–6 business process re-engineering 226, 295–300 business start-ups 208–11 Cadbury 9 career oaching 460 career exits 528 career myths 45–6 celebrity CEOs 184 centralization 188 CEOs celebrity 184 education 426–7 pay 450–1 change strategies 288–9 charisma 410 Chartered Institute of Personnel and Development (UK) 47 CHD (coronary heart disease) 163–4, 173 Chief Human Resources Officers 49 chief learning officers 462–3 China culture 137–9 management skills 147 multinational enterprises 130 CHRO (Chief Human Resources Officers) 49 CIPD (Chartered Institute of Personnel and Development) 47 CLE (Council for Legal Education) 379 cloning 349 CLOs (chief learning officers) 462–3 club culture 224 coaching 460–1 coercion by means of observation 6 collaborative entrepreneurship 211–12 collective bargaining 12, 30, 515 collectiv e performance schemes 444 collectivism 135–7, 138 collectivization 512–13 commitment 5, 36, 236–9 see also employee engagement Australia 245 culture 239–41 justification of 243–7 total quality management 241 United Kingdom 246 company rules 526–7 compensation 432–3 competence(s) 5, 36, 428 competitive market theories 103–5 competitiveness 4, 89–90 complexity of organisations 5 conflict 528–9 conflict management 512–33 Confucianism 131 congruence 36 construction industry 147 contingency 10 contingent employees 124 control, locus of 415–16 cooperation 4 cooperatives 185–6 coordination 6, 186 core workers 158 coronary heart disease 163–4, 173 corporate branding 249 corporate culture 10, 217–19 club culture 224 cultural network 220–1 Deal and Kennedy model 220–1 heroes 220 knowledge management 230–1 people management 223–5 person culture 224 rites and ritu als 220 role culture 224 task culture 224 values 220 cost-effectiveness 36 Council for Legal Education 379 counselling interviews 426–7 Craft Partnership 233 critical incidents technique 334 559

Free Essays on Virgina Satirs Humanistic Therapy Theory

Virginia Satir differed from other family therapy theorists in that her methods focus on the positive or healthy aspects of the family rather than the â€Å"problem†. She believed that the â€Å"problems† that arose within a family were based upon the healthy intentions of its members, which were not expressed in an authentic manner. This resulted in a variety of communication breakdowns in the family and the inability of the family members to express their feelings in an authentic manner. Satir used therapy to build self-esteem and to allow the clients to grow in a healthy way through various therapeutic techniques (Lawson & Prevatt, 1999). In Satir’s model there are four communication styles that are adopted by family members when they are afraid to voice their true feelings. She labels these as poses and it is the therapist’s job to allow the family to feel comfortable enough to be able to recognize the poses and show their authentic feelings. The poses are placating (weak, dependent), blaming (superior, accusatory), computing (cold, analytical), and distracting (refuses to acknowledge situation). Gentle, guiding techniques are used in this therapy (Lawson & Prevatt, 1999). To help the family members recognize the poses they assume and help them to discuss their authentic feelings, Andreas (1991) reviewed and identified seven main themes for a therapist to follow when using Satir’s approach: 1. Focusing therapy on the positive outcome rather than the traumatic past event or problem. 2. All people are inherently good and most intentions are positive even if they appear not to be; thus the therapist needs to develop a gentle and comforting relationship with the clients. 3. Look to develop healthy interactions between family members rather than fixate on destructive behaviors. 4. Therapists are more like life coaches than authoritative dictators in therapy. The more gentle the therapist, the more comfortable the cl... Free Essays on Virgina Satirs Humanistic Therapy Theory Free Essays on Virgina Satirs Humanistic Therapy Theory Virginia Satir differed from other family therapy theorists in that her methods focus on the positive or healthy aspects of the family rather than the â€Å"problem†. She believed that the â€Å"problems† that arose within a family were based upon the healthy intentions of its members, which were not expressed in an authentic manner. This resulted in a variety of communication breakdowns in the family and the inability of the family members to express their feelings in an authentic manner. Satir used therapy to build self-esteem and to allow the clients to grow in a healthy way through various therapeutic techniques (Lawson & Prevatt, 1999). In Satir’s model there are four communication styles that are adopted by family members when they are afraid to voice their true feelings. She labels these as poses and it is the therapist’s job to allow the family to feel comfortable enough to be able to recognize the poses and show their authentic feelings. The poses are placating (weak, dependent), blaming (superior, accusatory), computing (cold, analytical), and distracting (refuses to acknowledge situation). Gentle, guiding techniques are used in this therapy (Lawson & Prevatt, 1999). To help the family members recognize the poses they assume and help them to discuss their authentic feelings, Andreas (1991) reviewed and identified seven main themes for a therapist to follow when using Satir’s approach: 1. Focusing therapy on the positive outcome rather than the traumatic past event or problem. 2. All people are inherently good and most intentions are positive even if they appear not to be; thus the therapist needs to develop a gentle and comforting relationship with the clients. 3. Look to develop healthy interactions between family members rather than fixate on destructive behaviors. 4. Therapists are more like life coaches than authoritative dictators in therapy. The more gentle the therapist, the more comfortable the cl...

How to Remove Ball Point Pen Ink

How to Remove Ball Point Pen Ink Ballpoint pen ink is not something that you can usually remove with simple soap and water, but there is an easy and inexpensive way to remove pen ink from surfaces or clothing. Materials You Will Need to Remove Pen Ink You can use any of a number of common household chemicals to lift away ink. The best of these is alcohol, because it dissolves pigments that are soluble in both water and organic solvents and because its gentle enough that it wont discolor or damage most fabrics. Rubbing alcohol (isopropyl alcohol)Shaving cream (if the alcohol doesnt remove the ink)Hairspray (if neither the alcohol nor shaving cream works)Non-flammable dry cleaning fluid (another option) Ink Removal Instructions Dab rubbing alcohol onto the ink.Allow a couple of minutes for the alcohol to penetrate the surface and react with the ink.Blot the ink stain using layers of white paper towels or a cloth that has been dampened in either alcohol or water.If the alcohol is ineffective, try using foaming shaving cream.If the shaving cream doesnt work, hairspray usually will remove ink, but it should only be used as a last resort because hairspray damages some surfaces and fabrics.A non-flammable dry cleaning fluid may remove certain inks. If you use dry cleaning fluid to remove a stain, rinse the area with water afterward. Gel ink pens use an ink that is made to be permanent. Alcohol will not remove gel ink, nor will acid. Sometimes it is possible to wear away gel ink using an eraser. Ink stains in wood usually involve gouges in the wood, which makes it harder to get to the ink. Be sure to remove all traces of alcohol from the wood after the ink has been removed, rinse the affected area with water, and condition the wood to help reverse the drying effects of the alcohol. Why Ballpoint Ink is So Hard to Remove The reason ballpoint pen ink is so tricky to remove is its chemical composition. Ballpoint pens and felt-tip markers consist of pigments and dyes suspended in water and organic solvents, which may include toluene, glyco-ethers, propylene glycol, and propyl alcohol. Other ingredients may be added to help the ink flow or stick to the page, such as resins, wetting agents, and preservatives. Basically, removing the ink requires a solvent that works with both polar (water) and nonpolar (organic) molecules. Because of the nature of the ink, its important to remove the stain before dry cleaning, because the solvents used in the process can release the stain and spread it to other parts of the fabric.

Describing some of the rhetorical choices Essay Example | Topics and Well Written Essays - 500 words

Describing some of the rhetorical choices - Essay Example In the McDonald’s ad, there are several rhetorical choices that are evident. One is the use of hyperbole as a means to exaggerate the obsession for McDonald’s fare among the NFL players and coaches, in the middle of games. The first person mentions the menu, and the obsession becomes a kind of backdrop rap melody that the other characters then rapped to. The words that were put into their mouths consisted of variations of the burger fare, and an emphasis on bacon. There is also an element of parody as a rhetorical choice for the ad, where the intense obsession with what the players and coaches are saying on court, via lip reading, is flipped on its head so that their utterances are not about the game but about McDonald’s burgers (Super Bowl 2014 Commercials; Broderick). The rhetorical situation in the Toyota Highlander ad, on the other hand, is essentially the same as for the McDonald’s as well as for the all of the commercials in the Super Bowl. That rhetorical situation consists of the ads trying to convey the product message to TV viewers and general Internet followers of the Super Bowl ads. In the Toyota ad it is clear that the overall goal seems to be to entertain and to associate the Camry with images of fun and the iconic Muppets characters. Juxtaposition is a key rhetorical choice for this ad. The juxtaposition consists of the side by side placement of a relatively conventional, middle-class African American man who lives in the suburbs and drives around in a Highlander on the one hand, and on the other hand the psychedelic gang of the musical Muppets, headed by the wild Animal. This is a very good rhetorical choice, given that the Toyota’s traditional image is one of being practical and reliable, if utilitarian and lacking in the fun aspect. On the other hand, the juxtaposition with spontaneity, adventure and fun as embodied by the Muppets and by the Animal